Hydrogen Bromide → HCID 68898104, compound

HRID 659994Notes

Reaction equation

HRID 659994 reaction equation
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[C:6]([O:15]C)[C:7]([Cl:14])=[CH:8][C:9]=2[Cl:13])[N:4]=[CH:3]1.[BrH:17]>>[BrH:17].[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[C:6]([OH:15])[C:7]([Cl:14])=[CH:8][C:9]=2[Cl:13])[N:4]=[CH:3]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 59242633HCID 59242633, compound

Product 1

HCID 68898104HCID 68898104, compoundYield 58%

Procedure

A solution of 5-3 (60 mg, 0.231 mmol) and 48% aqueous hydrobromic acid (2 mL) was heated at 120° C. for 2 h. The solution was cooled to room temperature and the precipitate was isolated via filtration, washed successively with dichloromethane and diethyl ether, and dried in vacuo to provide 3-amino-5,7-dichloro-8-hydroxy-3H-quinazolin-4-one hydrobromide (5-4) as a white solid (44 mg, 58%).

Workup

  1. customthe precipitate was isolated via filtration
  2. washwashed successively with dichloromethane and diethyl ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-0f68f65f3a0948e6b4a2eba7f99c9f5f
Source dataset
uspto-grants-2011_12
Patent number
US08084459B2

Reaction notes

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