反应详情

132 mg (0.81 mmol) of CDI were added to a solution of 250 mg (0.77 mmol) of 2-(2-(phenylsulfonyl)ethylthio)nicotinic acid in DCM (6 ml), and the mixture was stirred for 1 h at RT. A solution of 82 mg (0.77 mmol) of benzylamine in DCM (6 ml) was then added, and stirring was continued for a further 16 hours at RT. The reaction solution was then washed in each case three times with a sat. aq. ammonium chloride solution and saturated aqueous NaHCO3 solution. The organic phase was dried over MgSO4, filtered and concentrated in vacuo. 266 mg (0.64 mmol, 83%) of N-benzyl-2-(2-(phenylsulfonyl)ethylthio)nicotinamide were obtained as residue.

1. stirringstirring
2. waitwas continued for a further 16 hours at RT
3. washThe reaction solution was then washed in each case three times with a sat. aq. ammonium chloride solution and saturated aqueous NaHCO3 solution
4. dry with materialThe organic phase was dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo