Phenylglyoxylic Acid → Hydroxy-(2-methoxy-phenyl)-phenyl-acetic acid

HRID 660074Notes

Reaction equation

HRID 660074 reaction equation
[OH:1][C:2]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1C)[C:3]([OH:5])=[O:4].Br[CH2:20][O:21]C1C=CC=CC=1.C(C(O)=O)(=O)C1C=CC=CC=1.COC(C(C1C=CC=CC=1)=O)=O>>[OH:1][C:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:21][CH3:20])([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]([OH:5])=[O:4]

Participants

5

Reactant 4

HCID 11915Phenylglyoxylic AcidHCID 84835Methyl phenylglyoxalateHCID 226676Hydroxy-phenyl-o-tolyl-acetic acid2×HCID 13097734p-Bromo methoxybenzene

Product 1

HCID 67538364Hydroxy-(2-methoxy-phenyl)-phenyl-acetic acid

Procedure

This compound is prepared by an analogous method to hydroxy-phenyl-o-tolyl-acetic acid (Intermediate M) by replacing bromotoluene with 2-bromomethoxy benzene and benzoyl formic acid with methyl benzoyl formate.

Sources & evidence

ORD record
ord-0231db966997450ca636306a19a811fc
Source dataset
uspto-grants-2011_12
Patent number
US08084463B2

Reaction notes

Loading…