反应详情

A solution of cyclohexyl-hydroxy-thiophen-2-yl-acetic acid ethyl ester (361.8 g, 1.35 mol) in MeOH (1.5 litres) and THF (1.5 litres) is treated portionwise with 2M NaOH (1.1 litres) over 30 minutes. The reaction mixture is stirred at room temperature overnight and then concentrated in vacuo to remove the organic solvents. The remaining aqueous portion is partitioned between EtOAc (2 litres) and 20% citric acid in water (1 litre). The organic layer is separated, washed with brine and concentrated in vacuo to afford the titled compound which is used crude in the next step.

1. concentrationconcentrated in vacuo
2. customto remove the organic solvents
3. customThe remaining aqueous portion is partitioned between EtOAc (2 litres) and 20% citric acid in water (1 litre)
4. customThe organic layer is separated
5. washwashed with brine
6. concentrationconcentrated in vacuo