Cyclohexylphenylglycolic acid, (-)- → (R)-Cyclohexyl-hydroxy-phenyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

HRID 660084Notes

Reaction equation

HRID 660084 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](=[O:24])[C@:11]([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)([OH:17])[C:12]1S[CH:14]=[CH:15][CH:16]=1)[CH2:2]2.[CH:25]1([C@@](O)(C2C=CC=CC=2)C(O)=O)CCCC[CH2:26]1>>[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](=[O:24])[C@:11]([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)([OH:17])[C:12]1[CH:26]=[CH:25][CH:14]=[CH:15][CH:16]=1)[CH2:2]2

Participants

3

Reactant 2

HCID 777377Cyclohexylphenylglycolic acid, (-)-HCID 66959049(S)-cyclohexyl-hydroxy-thiophen-2-yl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

Product 1

HCID 10831243(R)-Cyclohexyl-hydroxy-phenyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

Procedure

This compound is prepared analogously to (S)-cyclohexyl-hydroxy-thiophen-2-yl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester by replacing (S)-cyclohexyl-hydroxy-thiophen-2-yl-acetic acid with (R)-cyclohexyl-hydroxy-phenyl-acetic acid.

Sources & evidence

ORD record
ord-9ee0df1259764a9aad2bc237d46a2a40
Source dataset
uspto-grants-2011_12
Patent number
US08084463B2

Reaction notes

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