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A mixture of 25.2 g. of sodium bicarbonate, 12.3 g. of 2-aminopyridine and 30 g. of α-bromo-p-methoxyacetophenone in 100 ml. of water and 550 ml. of absolute ethanol is heated at reflux temperatures for 1.5 hrs. The reaction mixture is concentrated under reduced pressure to a yellow solid, which is partitioned between chloroform and water. The organic layer is separated, dried over sodium sulfate. Removal of the chloroform in vacuo leaves the crude intermediate as a yellow solid. Recrystallization from ethanolwater give 15.2 g. of the desired material, m.p. 131-134° C.

1. additionA mixture of 25.2 g
2. temperatureat reflux temperatures for 1.5 hrs
3. concentrationThe reaction mixture is concentrated under reduced pressure to a yellow solid, which
4. customis partitioned between chloroform and water
5. customThe organic layer is separated
6. dry with materialdried over sodium sulfate
7. customRemoval of the chloroform in vacuo