反应详情

Imidazo[1,5-a]pyridine (3.9 g.) in 100 ml. of dry acetonitrile is treated with 6.8 g. of α-bromotoluene, and the resulting reaction mixture heated under reflux for 3 hrs. The solution is cooled and diluted with 250 ml. of diethyl ether. The resulting precipitate is filtered and recrystallized from isopropanol-diethyl ether, 7.92 g., m.p. 172-176° C.

1. temperatureheated
2. temperatureunder reflux for 3 hrs
3. temperatureThe solution is cooled
4. additiondiluted with 250 ml
5. filtrationThe resulting precipitate is filtered
6. customrecrystallized from isopropanol-diethyl ether, 7.92 g