3-Fluoro-6-(methylamino)pyridine → Methyl 5-chloro-2-{[(5-fluoropyridin-2-yl)(methyl)amino]methyl}benzoate

HRID 660247Notes

Reaction equation

HRID 660247 reaction equation
BrC[CH2:3][C:4]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7].[F:15][C:16]1[CH:17]=[CH:18][C:19]([NH:22][CH3:23])=[N:20][CH:21]=1>>[Cl:14][C:11]1[CH:12]=[CH:13][C:4]([CH2:3][N:22]([C:19]2[CH:18]=[CH:17][C:16]([F:15])=[CH:21][N:20]=2)[CH3:23])=[C:5]([CH:10]=1)[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 591496673-Fluoro-6-(methylamino)pyridineHCID 68983888Methyl 2-(bromoethyl)-5-chlorobenzoate

Product 1

HCID 68863698Methyl 5-chloro-2-{[(5-fluoropyridin-2-yl)(methyl)amino]methyl}benzoate

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 22 from methyl 2-(bromoethyl)-5-chlorobenzoate and 5-fluoro-N-methylpyridin-2-amine (step 1):

Sources & evidence

ORD record
ord-600c13ef77a24d91a559d2448773861c
Source dataset
uspto-grants-2011_12
Patent number
US08084476B2

Reaction notes

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