2-(3-Nitro-4-hydroxyphenyl)propionic acid → HCID 12202637, compound

HRID 660338Notes

Reaction equation

HRID 660338 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[N+:13]([O-])=O>C1COCC1.CCO.[Pd]>[NH2:13][C:3]1[CH:4]=[C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])[CH:6]=[CH:7][C:2]=1[OH:1]

Participants

5

Reactant 1

HCID 128726092-(3-Nitro-4-hydroxyphenyl)propionic acid

Product 1

HCID 12202637HCID 12202637, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of (1) (810 mg, 1 mmol) in THF (20 ml) and EtOH (20 ml) is slowly added to 10% Pd/C (90 mg) at room temperature. The reaction mixture is hydrogenated for 3 h with H2 balloon at 45 psi. The mixture is filtered through celite pad and washed with EtOH. The filtrate is concentrated in vacuo.

Workup

  1. filtrationThe mixture is filtered through celite pad
  2. washwashed with EtOH
  3. concentrationThe filtrate is concentrated in vacuo

Sources & evidence

ORD record
ord-077845afd7a248b28d38cdf51c8db7cd
Source dataset
uspto-grants-2011_12
Patent number
US08084484B2

Reaction notes

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