Hydrazine hydrate (1:1) → HCID 67243107, compound

HRID 660359Notes

Reaction equation

HRID 660359 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([F:12])[C:3]=1F.O.[NH2:15][NH2:16]>C(O)C>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([F:12])[C:3]=1[NH:15][NH2:16]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 27770141,2,3-trifluoro-5-(trifluoromethyl)benzene

Product 1

HCID 67243107HCID 67243107, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1,2,3-trifluoro-5-(trifluoromethyl)benzene (300 g, 1.5 mmol) and hydrazine monohydrate (300 g, 6.0 mmol) in ethanol (1200 ml) was heated at reflux overnight. The reaction mixture was concentrated in vacuo and the residue was re-crystallised from 2-propanol to give Preparation 21 (194 g).

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationThe reaction mixture was concentrated in vacuo
  4. customthe residue was re-crystallised from 2-propanol
  5. customto give

Sources & evidence

ORD record
ord-8ce968bcbff343e7af78f7106cf40927
Source dataset
uspto-grants-2011_12
Patent number
US08084486B2

Reaction notes

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