Sulfamide → HCID 11379214, compound

HRID 660407Notes

Reaction equation

HRID 660407 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][CH:2]1[CH2:10][NH2:11].[S:12](N)([NH2:15])(=[O:14])=[O:13]>O1CCOCC1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][CH:2]1[CH2:10][NH:11][S:12]([NH2:15])(=[O:14])=[O:13]

Participants

4

Reactant 2

HCID 82267SulfamideHCID 573560261-(2H-1,3-Benzodioxol-2-yl)methanamine

Product 1

HCID 11379214HCID 11379214, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

C-Benzo[1,3]dioxol-2-yl-methylamine (2.94 g, 19.4 mmol) and sulfamide (3.74 g, 38.9 mmol) were combined in dry dioxane (50 mL) and the solution was heated to reflux overnight. The reaction was concentrated and the residue was chromatographed (2% to 10% acetone in dichloromethane) to yield the title compound as a white solid.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux overnight
  3. concentrationThe reaction was concentrated
  4. customthe residue was chromatographed (2% to 10% acetone in dichloromethane)

Sources & evidence

ORD record
ord-eabaee2b2a0f48f69c0d38e71d574dcc
Source dataset
uspto-grants-2011_12
Patent number
US08084490B2

Reaction notes

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