Sodium Methoxide → HCID 68839456, compound

HRID 660485Notes

Reaction equation

HRID 660485 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH:15](Br)[CH:16]([Br:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[N:25]1[S:29](=[O:31])(=[O:30])[NH:28][C:27](=[O:32])[CH2:26]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:33][O-:34].[Na+]>CO.C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH:15]([O:34][CH3:33])[CH:16]([Br:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[N:25]1[S:29](=[O:31])(=[O:30])[NH:28][C:27](=[O:32])[CH2:26]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 68839807HCID 68839807, compound

Product 1

HCID 68839456HCID 68839456, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

To a stirred solution of 5-[2-benzyloxy-4-(1,2-dibromo-2-phenylethyl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one (25 mg, 0.043 mmol) in MeOH/methylene chloride (1:1, 4 mL) is added NaOMe (0.17 mL, 0.086 mmol, 0.5M in THF). The solution is stirred at RT for 2 h and the solvent is removed under reduced pressure to give the title compound as a yellow solid.

Workup

  1. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-d69a816039ff44f4a2deb5d516db4bd6
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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