反应详情

温度

60 °C

A mixture of 5-{2-benzyloxy-4-[(E)-2-(2-benzyloxymethyl-2H-pyrazol-3-yl)-vinyl]-phenyl}-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one (330 mg, 0.50 mmol)) and CsF (400 mg, 2.6 mmol) in DMF (5 mL) is heated at 60° C. for 18 h. The mixture is partitioned between aqueous NH4Cl and EtOAc and the organic layer is concentrated to afford the title compound which is used directly in the next step: (M+1)+=531.

1. customThe mixture is partitioned between aqueous NH4Cl and EtOAc
2. concentrationthe organic layer is concentrated