Tert-butyl 3-(iodomethyl)piperidine-1-carboxylate → 3-{3-Benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-benzyl}-piperidine-1-carboxylic Acid Tert-butyl Ester

HRID 660529Notes

Reaction equation

HRID 660529 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14]I)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:16]([O:23][C:24]1[CH:29]=[C:28](I)[CH:27]=[CH:26][C:25]=1[N:31]1[S:35](=[O:37])(=[O:36])[N:34]([CH2:38][CH2:39][Si:40]([CH3:43])([CH3:42])[CH3:41])[C:33](=[O:44])[CH2:32]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][C:28]2[CH:27]=[CH:26][C:25]([N:31]3[CH2:32][C:33](=[O:44])[N:34]([CH2:38][CH2:39][Si:40]([CH3:43])([CH3:42])[CH3:41])[S:35]3(=[O:37])=[O:36])=[C:24]([O:23][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:29]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 20716152Tert-butyl 3-(iodomethyl)piperidine-1-carboxylateHCID 667569375-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one

Product 1

HCID 688423073-{3-Benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-benzyl}-piperidine-1-carboxylic Acid Tert-butyl Ester

Procedure

The title compound is prepared from 3-iodomethylpiperidine-1-carboxylic acid tert-butyl ester and 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one analogous to the method used in Example 57, step B.

Sources & evidence

ORD record
ord-1fc5368b6f3848b5b4586cad36e17778
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

Loading…