HCID 68839644, compound → HCID 68839806, compound

HRID 660594Notes

Reaction equation

HRID 660594 reaction equation
C([O:5][C:6](=[O:37])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:19][C:18](=[O:20])[N:17]([CH2:21][CH2:22][Si:23]([CH3:26])([CH3:25])[CH3:24])[S:16]2(=[O:28])=[O:27])=[C:11]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:10]=1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH2:30]([O:29][C:11]1[CH:10]=[C:9]([CH2:8][CH2:7][C:6]([OH:37])=[O:5])[CH:14]=[CH:13][C:12]=1[N:15]1[CH2:19][C:18](=[O:20])[N:17]([CH2:21][CH2:22][Si:23]([CH3:24])([CH3:25])[CH3:26])[S:16]1(=[O:28])=[O:27])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

3

Reactant 1

HCID 68839644HCID 68839644, compound

Product 1

HCID 68839806HCID 68839806, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of 3-{3-benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-phenyl}-propionic acid tert-butyl ester (420 mg, 0.77 mmol) in 6 mL of TFA/methylene chloride (1:1) is stirred at RT for 20 min. The solvent is removed under reduced pressure. Methylene chloride is added and removed (4×) to give the title compound as an oil: (M−1)−=489.

Workup

  1. customThe solvent is removed under reduced pressure
  2. additionMethylene chloride is added
  3. customremoved (4×)

Sources & evidence

ORD record
ord-1457113b9f634d5e9925f60dbf43cf85
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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