2-(4-Aminobutoxy)-6-benzyloxybenzoic Acid Methyl Ester → 2-(4-{(S)-2-Acetylamino-3-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-propionylamino}-butoxy)-6-benzyloxybenzoic Acid Methyl Ester

HRID 660639Notes

Reaction equation

HRID 660639 reaction equation
[C:1]([NH:4][C@@H:5]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:20][C:19](=[O:21])[NH:18][S:17]2(=[O:23])=[O:22])=[C:12]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:11]=1)[C:6](O)=[O:7])(=[O:3])[CH3:2].[CH3:32][O:33][C:34](=[O:55])[C:35]1[C:40]([O:41][CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)=[CH:39][CH:38]=[CH:37][C:36]=1[O:49][CH2:50][CH2:51][CH2:52][CH2:53][NH2:54]>>[CH3:32][O:33][C:34](=[O:55])[C:35]1[C:40]([O:41][CH2:42][C:43]2[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=2)=[CH:39][CH:38]=[CH:37][C:36]=1[O:49][CH2:50][CH2:51][CH2:52][CH2:53][NH:54][C:6](=[O:7])[C@@H:5]([NH:4][C:1](=[O:3])[CH3:2])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:20][C:19](=[O:21])[NH:18][S:17]2(=[O:23])=[O:22])=[C:12]([O:24][CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 684293722-(4-Aminobutoxy)-6-benzyloxybenzoic Acid Methyl EsterHCID 68838960(S)-2-Acetylamino-3-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-propionic Acid

Product 1

HCID 689221272-(4-{(S)-2-Acetylamino-3-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-propionylamino}-butoxy)-6-benzyloxybenzoic Acid Methyl Ester

Procedure

The title compound is prepared using (S)-2-acetylamino-3-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-propionic acid and 2-(4-aminobutoxy)-6-benzyloxybenzoic acid methyl ester (Example 110, step C) analogous to Example 131, step C.

Sources & evidence

ORD record
ord-1e2156cde31e4beabed31d8f1ec4bbb6
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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