Trifluoroacetic acid → HCID 68839756, compound

HRID 660671Notes

Reaction equation

HRID 660671 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH2:25][C:24](=[O:26])[N:23]([CH2:27][CH2:28][Si:29]([CH3:32])([CH3:31])[CH3:30])[S:22]2(=[O:34])=[O:33])=[C:17]([O:35][CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:16]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[S:22](=[O:34])(=[O:33])[N:23]([CH2:27][CH2:28][Si:29]([CH3:31])([CH3:32])[CH3:30])[C:24](=[O:26])[CH2:25]2)=[C:17]([O:35][CH2:36][C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68839056HCID 68839056, compound

Product 1

HCID 68839756HCID 68839756, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of ((1R*,2S*)-2-{3-benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-benzyl}-cyclohexyl)-carbamic acid tert-butyl ester (Example 66, step C) (450 mg, 0.714 mmol) in methylene chloride (5 mL) is added TFA (5 mL) and the solution is stirred at RT for 15 min. The solvent is removed under reduced pressure to give the title compound which is used directly in the next step.

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-702a8f09e0344914990456dffa31b8d0
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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