HRID660683

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6386

tert-Butyl alcohol

C4H10O

HCID70918

Sulfuryl chloride isocyanate

CClNO3S

结构：C[Si](C)(C)CCN1C(=O)CN(c2ccc(CCN)cc2OCc2ccccc2)S1(=O)=O.O=C(O)C(F)(F)F

HCID86632572

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NS(=O)(=O)NCCc1ccc(N2CC(=O)N(CC[Si](C)(C)C)S2(=O)=O)c(OCc2ccccc2)c1

HCID86632582

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from 5-[4-(2-aminoethyl)-2-benzyloxyphenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one TFA salt (Example 67, step A), chlorosulfonyl isocyanate and t-butanol analogous to Example 55, step D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-33e5dd6bc5634f58a35281f87e1fb85d
来源数据集: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08084448B2
来源说明: uspto-grants-2011_12

反应 SMILES

OC(C(F)(F)F)=O.[NH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]2[S:21](=[O:23])(=[O:22])[N:20]([CH2:24][CH2:25][Si:26]([CH3:29])([CH3:28])[CH3:27])[C:19](=[O:30])[CH2:18]2)=[C:13]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:12]=1.Cl[S:40]([N:43]=[C:44]=[O:45])(=[O:42])=[O:41].[C:46]([OH:50])([CH3:49])([CH3:48])[CH3:47]>>[O:22]=[S:21]1(=[O:23])[N:20]([CH2:24][CH2:25][Si:26]([CH3:27])([CH3:28])[CH3:29])[C:19](=[O:30])[CH2:18][N:17]1[C:14]1[CH:15]=[CH:16][C:11]([CH2:10][CH2:9][NH:8][S:40]([NH:43][C:44](=[O:45])[O:50][C:46]([CH3:49])([CH3:48])[CH3:47])(=[O:42])=[O:41])=[CH:12][C:13]=1[O:31][CH2:32][C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1