HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butanol → Tert-Butyl [({2-[4-(1,1-dioxido-4-oxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl)-3-benzyloxyphenyl]ethyl}amino)sulfonyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Chlorosulfonyl isocyanate | HCID 70918 | — |
| Reactant | 5-[4-(2-Aminoethyl)-2-benzyloxyphenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one TFA Salt | HCID 86632572 | — |
| Product | Tert-Butyl [({2-[4-(1,1-dioxido-4-oxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl)-3-benzyloxyphenyl]ethyl}amino)sulfonyl]carbamate | HCID 86632582 | — |
Reaction Steps
The title compound is prepared from 5-[4-(2-aminoethyl)-2-benzyloxyphenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one TFA salt (Example 67, step A), chlorosulfonyl isocyanate and t-butanol analogous to Example 55, step D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084448B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-33e5dd6bc5634f58a35281f87e1fb85d |
| Source note | uspto-grants-2011_12 |