反应详情

To a solution of 2-benzyloxy-4-bromomethyl-1-nitrobenzene (Example 83, step C) (1.0 g, 3.1 mmol) in 20 mL DMF is added sodium thiomethoxide (228 mg, 3.26 mmol). The solution is stirred at RT for 2 h then water is added and the mixture is extracted with EtOAc. The organic layer is washed with water and brine, and dried over sodium sulfate. The solvent is removed under reduced pressure to give the title compound as a yellow liquid.

1. extractionthe mixture is extracted with EtOAc
2. washThe organic layer is washed with water and brine
3. dry with materialdried over sodium sulfate
4. customThe solvent is removed under reduced pressure