5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one → HCID 57777373, compound

HRID 660693Notes

Reaction equation

HRID 660693 reaction equation
C([O:8][C:9]1[CH:14]=[C:13](I)[CH:12]=[CH:11][C:10]=1[N:16]1[S:20](=[O:22])(=[O:21])[N:19](CC[Si](C)(C)C)[C:18](=[O:29])[CH2:17]1)C1C=CC=CC=1.I[CH2:31][CH2:32][CH2:33][CH2:34][S:35]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)(=[O:37])=[O:36]>>[C:38]1([S:35]([CH2:34][CH2:33][CH2:32][CH2:31][C:13]2[CH:12]=[CH:11][C:10]([N:16]3[S:20](=[O:21])(=[O:22])[NH:19][C:18](=[O:29])[CH2:17]3)=[C:9]([OH:8])[CH:14]=2)(=[O:37])=[O:36])[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1

Participants

3

Reactant 2

HCID 667569375-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-oneHCID 68842558HCID 68842558, compound

Product 1

HCID 57777373HCID 57777373, compound

Procedure

The title compound is prepared from 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one and (4-iodobutane-1-sulfonyl)-benzene analogous to Example 57, steps B, C and D: (M−1)−=423. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.49-1.60 (m, 4 H) 2.40 (t, J=6.69 Hz, 2 H) 4.01 (s, 2 H) 6.46 (s, 1 H) 6.58 (s, 1 H) 7.21 (d, J=7.83 Hz, 1 H) 7.65 (t, J=7.58 Hz, 2 H) 7.71-7.77 (m, 1 H) 7.85-7.90 (m, 2 H)

Sources & evidence

ORD record
ord-56d48295471c406f9aed90e19c3dd8d3
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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