反应详情

温度

110 °C

A mixture of 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (100 mg, 0.225 mmol), 1-propyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (106 mg, 0.45 mmol), resin-bound PPh3Pd (177 mg, loading 0.13 mmol/g) and aqueous Na2CO3 (0.45 mL of a 2M solution) in DME (3 mL) is heated in a microwave apparatus at 110° C. for 10 min. The mixture is filtered and the solvent removed under reduced pressure to give the title compound which is used directly in the next step.

1. filtrationThe mixture is filtered
2. customthe solvent removed under reduced pressure