HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 660738Generated: October 30, 2026
Sodium Carbonate → 5-[2-Benzyloxy-4-(1-propyl-1H-pyrazol-4-yl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-4-one
https://huagongshe.com/reaction/660738
Participants
| Role | Name | HCID | Charge |
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| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-Propyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 2760487 | — |
| Reactant | 5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one | HCID 68838643 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 5-[2-Benzyloxy-4-(1-propyl-1H-pyrazol-4-yl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-4-one | HCID 68996269 | — |
Reaction Steps
A mixture of 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (100 mg, 0.225 mmol), 1-propyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (106 mg, 0.45 mmol), resin-bound PPh3Pd (177 mg, loading 0.13 mmol/g) and aqueous Na2CO3 (0.45 mL of a 2M solution) in DME (3 mL) is heated in a microwave apparatus at 110° C. for 10 min. The mixture is filtered and the solvent removed under reduced pressure to give the title compound which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08084448B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-c02dc77bd56e4e99ad705bb83c4cbc21 |
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| Source note | uspto-grants-2011_12 |
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