HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-(3-Benzyloxy-4-nitrophenoxy)-1,3,4,5-tetrahydrobenzo[b]azepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one | HCID 2757184 | — |
| Reactant | 3-(Benzyloxy)-4-nitrophenol | HCID 10977711 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(3-Benzyloxy-4-nitrophenoxy)-1,3,4,5-tetrahydrobenzo[b]azepin-2-one | HCID 68839552 | — |
Reaction Steps
A mixture of 3-benzyloxy-4-nitrophenol (2.45 g, 10 mmol), 3-bromo-1,3,4,5-tetrahydrobenzo[b]azepin-2-one (2.4 g, 10 mmol) and potassium carbonate (3.1 g, 23 mmol) in MeCN (10 mL) is refluxed for 10 h. Upon cooling a precipitate forms. The solid is filtered, washed with water and crystallized from EtOAc to give the title compound: mp=188-189° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084448B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-33d4ea35e13b4a1eaaef8144c5f2afdf |
| Source note | uspto-grants-2011_12 |