反应详情

A mixture of 3-benzyloxy-4-nitrophenol (2.45 g, 10 mmol), 3-bromo-1,3,4,5-tetrahydrobenzo[b]azepin-2-one (2.4 g, 10 mmol) and potassium carbonate (3.1 g, 23 mmol) in MeCN (10 mL) is refluxed for 10 h. Upon cooling a precipitate forms. The solid is filtered, washed with water and crystallized from EtOAc to give the title compound: mp=188-189° C.

1. temperatureis refluxed for 10 h
2. temperatureUpon cooling a precipitate forms
3. filtrationThe solid is filtered
4. washwashed with water
5. customcrystallized from EtOAc