反应详情

To a solution of 2-cyanomethylbenzoic acid methyl ester (1.75 g, 10 mmol) in THF (15 mL) is added LiBH4 (660 mg, 30 mmol) and the mixture is stirred at RT for 3 h. The mixture is quenched with MeOH then water is added. The mixture is extracted with EtOAc and the organic phase is washed with 1N HCl and brine then is dried over magnesium sulfate. The solvent is removed under reduced pressure to give the title compound which is used directly in the next step.

1. customThe mixture is quenched with MeOH
2. additionwater is added
3. extractionThe mixture is extracted with EtOAc
4. washthe organic phase is washed with 1N HCl and brine
5. dry with materialthen is dried over magnesium sulfate
6. customThe solvent is removed under reduced pressure