HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 660804Generated: October 28, 2026
Hydrochloric Acid → {2-[3-Hydroxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-phenyl}-acetic Acid
https://huagongshe.com/reaction/660804
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | {2-[3-Hydroxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-phenyl}-acetic acid methyl ester | HCID 57777352 | — |
| Solvent | Acetonitrile methanol water | HCID 21864137 | — |
| Product | {2-[3-Hydroxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-phenyl}-acetic Acid | HCID 57777381 | — |
Reaction Steps
To a solution of {2-[3-hydroxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-phenyl}-acetic acid methyl ester in water/MeOH/MeCN (1:1:1) is added KOH and the mixture is heated at 60° C. for 1 h. The mixture is cooled to RT and is acidified with 1N HCl. The mixture is purified by preparative HPLC to give the title compound. (M−1)−=375. HPLC retention time=0.63 min (Method A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08084448B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-f3a9c62cb204450b9ce723c79575eaf4 |
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| Source note | uspto-grants-2011_12 |
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