反应详情

温度

60 °C

To a solution of {2-[3-hydroxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-phenyl}-acetic acid methyl ester in water/MeOH/MeCN (1:1:1) is added KOH and the mixture is heated at 60° C. for 1 h. The mixture is cooled to RT and is acidified with 1N HCl. The mixture is purified by preparative HPLC to give the title compound. (M−1)−=375. HPLC retention time=0.63 min (Method A).

1. temperatureThe mixture is cooled to RT
2. customThe mixture is purified by preparative HPLC