2-Benzyloxy-4-methoxy-1-nitrobenzene → 2-(Benzyloxy)-4-methoxyaniline

HRID 660818Notes

Reaction equation

HRID 660818 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:10]=1[N+:17]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.[Pt]=O>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:10]=1[NH2:17])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 207885102-Benzyloxy-4-methoxy-1-nitrobenzene

Product 1

HCID 688378192-(Benzyloxy)-4-methoxyaniline

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-benzyloxy-4-methoxy-1-nitrobenzene (700 mg) in EtOAc (15 mL) is hydrogenated over platinum oxide (70 mg) at 20 psi for 1 h. The catalyst is filtered and the filtrate evaporated to give the title compound as an oil.

Workup

  1. filtrationThe catalyst is filtered
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-6a682c37e862430da89e21a59e91802b
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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