N-bromobutanimide → HCID 86632592, compound

HRID 660834Notes

Reaction equation

HRID 660834 reaction equation
C1C(=O)N([Br:8])C(=O)C1.[CH2:9]([O:16][C:17]1[C:22]([F:23])=[CH:21][C:20]([F:24])=[CH:19][C:18]=1[NH2:25])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(Cl)Cl>[CH2:9]([O:16][C:17]1[C:22]([F:23])=[C:21]([Br:8])[C:20]([F:24])=[CH:19][C:18]=1[NH2:25])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 68839799HCID 68839799, compound

Product 1

HCID 86632592HCID 86632592, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a suspension of NBS (1.60 g, 9.01 mmol) in methylene chloride (20 mL) at 0° C. is added a solution of 2-benzyloxy-3,5-difluorophenylamine (2.12 g, 9.01 mmol) and the mixture is stirred at 0° C. for 30 min then at RT for 30 min. The Mixture is washed with water and the solvent evaporated under reduced pressure. The residue is purified by column chromatography to give the title compound: MS (M−H)−=313.

Workup

  1. waitat RT for 30 min
  2. washThe Mixture is washed with water
  3. customthe solvent evaporated under reduced pressure
  4. customThe residue is purified by column chromatography

Sources & evidence

ORD record
ord-a767b17615094161bc5b4016613e3127
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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