反应详情

温度

50 °C

Under an argon atmosphere, 4.00 g (23.4 mmol) of 4-chlorobenzoic acid hydrazide are placed in 50 ml tetrahydrofuran. 1.95 g (23.4 mmol) of cyclopropyl isocyanate, dissolved in 50 ml tetrahydrofuran, are added dropwise at 50° C., and the mixture further stirred overnight at 50° C. The solvent is evaporated in vacuo, diethyl ether is added to the residue and the solid formed is isolated and purified by filtration and further washing with diethyl ether. 5.92 g (ca. 100% of theory) of the target compound are thus obtained.

1. additionare added dropwise at 50° C.
2. customThe solvent is evaporated in vacuo, diethyl ether
3. additionis added to the residue
4. customthe solid formed
5. customis isolated
6. filtrationpurified by filtration
7. washfurther washing with diethyl ether
8. custom5.92 g (ca. 100% of theory) of the target compound are thus obtained