反应详情

Under an argon atmosphere, 430 mg (2.52 mmol) of 3-chlorobenzoic acid hydrazide are placed in 6 ml tetrahydrofuran. 209 mg (2.52 mmol) of cyclopropyl isocyanate, dissolved in 2 ml tetrahydrofuran is added dropwise and further stirred overnight at room temperature. It is concentrated and purified by stirring the residue with diethyl ether, filtration, further washing with diethyl ether and drying in vacuo. 514 mg (80% of theory) of the target compound are thus obtained.

1. additionis added dropwise and further stirred overnight at room temperature
2. concentrationIt is concentrated
3. custompurified
4. filtrationwith diethyl ether, filtration
5. washfurther washing with diethyl ether
6. customdrying in vacuo
7. custom514 mg (80% of theory) of the target compound are thus obtained