反应详情

温度

50 °C

Under an argon atmosphere, 10.0 g (58.6 mmol) of 2-chlorobenzoic acid hydrazide is placed in 50 ml tetrahydrofuran. 4.87 g (58.6 mmol) of cyclopropyl isocyanate, dissolved in 50 ml tetrahydrofuran, are added dropwise at 50° C., and the mixture further stirred overnight at 50° C. The resulting precipitate is filtered off after cooling to room temperature and then washed with diethyl ether. 13.9 g (93% of theory) of the target compound are thus obtained.

1. additionare added dropwise at 50° C.
2. filtrationThe resulting precipitate is filtered off
3. temperatureafter cooling to room temperature
4. washwashed with diethyl ether
5. custom13.9 g (93% of theory) of the target compound are thus obtained