2-Chlorobenzohydrazide → 2-(2-chlorobenzoyl)-N-cyclopropylhydrazinecarboxamide

Participants

Reaction Conditions

Reaction Steps

Under an argon atmosphere, 10.0 g (58.6 mmol) of 2-chlorobenzoic acid hydrazide is placed in 50 ml tetrahydrofuran. 4.87 g (58.6 mmol) of cyclopropyl isocyanate, dissolved in 50 ml tetrahydrofuran, are added dropwise at 50° C., and the mixture further stirred overnight at 50° C. The resulting precipitate is filtered off after cooling to room temperature and then washed with diethyl ether. 13.9 g (93% of theory) of the target compound are thus obtained.

Provenance & Evidence