反应详情

1.00 g (4.71 mmol) of 2-phenylbenzoic acid hydrazide are placed in 10 ml tetrahydrofuran at room temperature. 0.51 g (5.15 mmol) of isobutyl isocyanate, dissolved in 2 ml tetrahydrofuran, are rapidly added dropwise with stirring. The mixture is firstly stirred further at room temperature and then allowed to stand overnight. Addition of an equal volume of diethyl ether and 10 ml of cyclohexane results in separation of a small quantity of a solid, which is filtered off and discarded. Concentration of the filtrate yields 1.53 g (ca. 100% of theory) of a slightly THF-moist product, which is used further as such.

1. additionare rapidly added dropwise
2. stirringThe mixture is firstly stirred further at room temperature
3. customresults in separation of a small quantity of a solid, which
4. filtrationis filtered off
5. customConcentration of the filtrate yields 1.53 g (ca. 100% of theory) of a slightly THF-moist product, which