反应详情

7.00 g (27.6 mmol) of 2-(2-chlorobenzoyl)-N-cyclopropylhydrazinecarboxamide from Example 10A are heated under reflux for about 60 hrs in 30 ml 3 N aqueous sodium hydroxide (conversion testing by LC/MS analysis). After cooling, it is acidified with 1 N hydrochloric acid and the mixture extracted three times with ethyl acetate. The combined organic phases are washed twice with saturated sodium hydrogen carbonate solution, dried over magnesium sulphate, filtered and concentrated. 3.32 g (48% of theory) of the target compound are thus obtained.

1. temperatureAfter cooling
2. extractionthe mixture extracted three times with ethyl acetate
3. washThe combined organic phases are washed twice with saturated sodium hydrogen carbonate solution
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. concentrationconcentrated
7. custom3.32 g (48% of theory) of the target compound are thus obtained