Hydrochloric Acid → HCID 58012054, compound

HRID 660851Notes

Reaction equation

HRID 660851 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][NH:9][C:10]([NH:12][CH2:13][CH2:14][O:15][CH3:16])=[O:11])=O)=[CH:4][CH:3]=1.Cl>[OH-].[Na+]>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]2[N:12]([CH2:13][CH2:14][O:15][CH3:16])[C:10](=[O:11])[NH:9][N:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 47133922HCID 47133922, compound

Product 1

HCID 58012054HCID 58012054, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

1.28 g (4.71 mmol) of 2-(4-chlorobenzoyl)-N-(2-methoxyethyl)-hydrazinecarboxamide from Example 13A are heated under reflux overnight in 10 ml 3 N aqueous sodium hydroxide. After cooling, it is acidified to about pH 2.5 with 1 N hydrochloric acid with ice-cooling and the resulting precipitate filtered off and dried in vacuo. 1.09 g (92% of theory) of the target compound, which is reacted without further purification, are thus obtained.

Workup

  1. temperatureAfter cooling
  2. temperaturecooling
  3. filtrationthe resulting precipitate filtered off
  4. customdried in vacuo
  5. custom1.09 g (92% of theory) of the target compound, which is reacted without further purification
  6. customare thus obtained

Sources & evidence

ORD record
ord-34fa904f9a1a4941b151916a33983f4b
Source dataset
uspto-grants-2011_12
Patent number
US08084481B2

Reaction notes

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