Hydrochloric Acid → 4-cyclopropyl-5-(2-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

HRID 660852Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 660852
[CH:1]1([NH:4][C:5]([NH:7][NH:8][C:9](=O)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])=[O:6])[CH2:3][CH2:2]1.Cl>[OH-].[Na+]>[CH:1]1([N:4]2[C:9]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[O:16][CH3:17])=[N:8][NH:7][C:5]2=[O:6])[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 47420312N-cyclopropyl-2-(2-methoxybenzoyl)-hydrazinecarboxamide

Produkt 1

HCID 580117694-cyclopropyl-5-(2-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

700 mg (2.81 mmol) of N-cyclopropyl-2-(2-methoxybenzoyl)-hydrazinecarboxamide from Example 14A are heated under reflux overnight in 10 ml 3 N aqueous sodium hydroxide. After cooling, it is acidified to pH 5-6 with dilute hydrochloric acid, and the mixture is concentrated and the residue purified by preparative HPLC [Method 12]. 240 mg (37% of theory) of the target compound are thus obtained.

Aufarbeitung

  1. temperatureAfter cooling
  2. concentrationthe mixture is concentrated
  3. customthe residue purified by preparative HPLC [Method 12]
  4. custom240 mg (37% of theory) of the target compound are thus obtained

Quellen und Nachweise

ORD-Eintrag
ord-b24114ee57964bff97cc1742874c0c36
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084481B2

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