反应详情

700 mg (2.81 mmol) of N-cyclopropyl-2-(2-methoxybenzoyl)-hydrazinecarboxamide from Example 14A are heated under reflux overnight in 10 ml 3 N aqueous sodium hydroxide. After cooling, it is acidified to pH 5-6 with dilute hydrochloric acid, and the mixture is concentrated and the residue purified by preparative HPLC [Method 12]. 240 mg (37% of theory) of the target compound are thus obtained.

1. temperatureAfter cooling
2. concentrationthe mixture is concentrated
3. customthe residue purified by preparative HPLC [Method 12]
4. custom240 mg (37% of theory) of the target compound are thus obtained