Hydrochloric Acid → 4-cyclopropyl-5-(2-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

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Reaction Steps

700 mg (2.81 mmol) of N-cyclopropyl-2-(2-methoxybenzoyl)-hydrazinecarboxamide from Example 14A are heated under reflux overnight in 10 ml 3 N aqueous sodium hydroxide. After cooling, it is acidified to pH 5-6 with dilute hydrochloric acid, and the mixture is concentrated and the residue purified by preparative HPLC [Method 12]. 240 mg (37% of theory) of the target compound are thus obtained.

Provenance & Evidence