Potassium Hydroxide → HCID 58011657, compound

HRID 660858Notes

Reaction equation

HRID 660858 reaction equation
C([O:3][C:4](=[O:23])[CH2:5][N:6]1[C:10](=[O:11])[N:9]([CH:12]2[CH2:14][CH2:13]2)[C:8]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH3:22])=[N:7]1)C.[OH-].[K+]>CO>[CH:12]1([N:9]2[C:10](=[O:11])[N:6]([CH2:5][C:4]([OH:23])=[O:3])[N:7]=[C:8]2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH3:22])[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 58011670HCID 58011670, compound

Product 1

HCID 58011657HCID 58011657, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

140 mg (0.44 mmol) of ethyl[4-cyclopropyl-3-(2-methoxyphenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate from Example 72A are placed in 0.3 ml methanol and stirred overnight at room temperature with 0.12 ml of 20% aqueous potassium hydroxide. This is then concentrated and adjusted to about pH 1 with 1 N hydrochloric acid. The precipitated solid is filtered off, washed with diethyl ether and then dried in vacuo. 81 mg (63% of theory) of the target compound are thus obtained.

Workup

  1. concentrationThis is then concentrated
  2. filtrationThe precipitated solid is filtered off
  3. washwashed with diethyl ether
  4. customdried in vacuo
  5. custom81 mg (63% of theory) of the target compound are thus obtained

Sources & evidence

ORD record
ord-c91e3990558145cc8f9f34b1b584536f
Source dataset
uspto-grants-2011_12
Patent number
US08084481B2

Reaction notes

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