Potassium Hydroxide → HCID 58011657, compound

Participants

Reaction Steps

140 mg (0.44 mmol) of ethyl[4-cyclopropyl-3-(2-methoxyphenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate from Example 72A are placed in 0.3 ml methanol and stirred overnight at room temperature with 0.12 ml of 20% aqueous potassium hydroxide. This is then concentrated and adjusted to about pH 1 with 1 N hydrochloric acid. The precipitated solid is filtered off, washed with diethyl ether and then dried in vacuo. 81 mg (63% of theory) of the target compound are thus obtained.

Provenance & Evidence