Potassium Hydroxide → HCID 58011738, compound

HRID 660861Notes

Reaction equation

HRID 660861 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]3[CH2:15][CH2:14]3)[C:11](=[O:16])[N:10]([CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])[N:9]=2)=[CH:4][CH:3]=1.[OH-].[K+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]3[CH2:15][CH2:14]3)[C:11](=[O:16])[N:10]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 58012236HCID 58012236, compound

Product 1

HCID 58011738HCID 58011738, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

560 mg (1.67 mmol) of ethyl 3-[3-(4-chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-propionate from Example 87A are placed in 1.5 ml methanol, treated with 0.5 ml 20% aqueous potassium hydroxide and stirred for 2 hrs at room temperature. The methanol is removed in vacuo, the aqueous residue acidified to pH 1 with 2 N hydrochloric acid and the resulting precipitate isolated by filtration. 439 mg (73% of theory) of the target compound are thus obtained.

Workup

  1. customThe methanol is removed in vacuo
  2. customthe resulting precipitate isolated by filtration
  3. custom439 mg (73% of theory) of the target compound are thus obtained

Sources & evidence

ORD record
ord-d6f2a436f12745bfa5ce817486b38eb8
Source dataset
uspto-grants-2011_12
Patent number
US08084481B2

Reaction notes

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