Potassium Hydroxide → HCID 58011738, compound

Participants

Reaction Steps

560 mg (1.67 mmol) of ethyl 3-[3-(4-chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-propionate from Example 87A are placed in 1.5 ml methanol, treated with 0.5 ml 20% aqueous potassium hydroxide and stirred for 2 hrs at room temperature. The methanol is removed in vacuo, the aqueous residue acidified to pH 1 with 2 N hydrochloric acid and the resulting precipitate isolated by filtration. 439 mg (73% of theory) of the target compound are thus obtained.

Provenance & Evidence