反应详情

温度

50 °C

Under argon, 1.99 g (33 mmol) of formylhydrazine are placed in 80 ml THF. The solution is heated to 50° C., treated dropwise with a solution of 5.00 g (33 mmol) of 2-fluorobenzyl isocyanate in 50 ml THF and the resulting mixture stirred for 30 mins more at 50° C. It is then freed of solvent on the rotary evaporator. The residue is stirred with diethyl ether, the precipitate suction-filtered, then washed with diethyl ether and the white solid dried under high vacuum. 5.73 g (82% of theory) of the target product are obtained.

1. customIt is then freed of solvent on the rotary evaporator
2. stirringThe residue is stirred with diethyl ether
3. filtrationthe precipitate suction-filtered
4. washwashed with diethyl ether
5. customthe white solid dried under high vacuum
6. custom5.73 g (82% of theory) of the target product are obtained