反应详情

A solution of 48 mg (117 μmol) of the compound from Example 223A in 2 ml methanol is treated with a 1 N lithium hydroxide solution in water (470 μl, 470 μmol). After 1 hr at RT, the methanol is removed on the rotary evaporator. The residue is dissolved in DMSO and purified by preparative HPLC. 41 mg (88% of theory) of the title compound are obtained.

1. customthe methanol is removed on the rotary evaporator
2. dissolutionThe residue is dissolved in DMSO
3. custompurified by preparative HPLC