Lithium Hydroxide → HCID 58011978, compound

Participants

Reaction Steps

770 mg (2.89 mmol) of methyl[4-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate from Example 232A are placed in 20 ml methanol, treated with 5.8 ml of 1 M aqueous lithium hydroxide solution and stirred for 18 hrs at room temperature. The methanol is then removed on the rotary evaporator and the residue is acidified with 1 N hydrochloric acid. The resulting precipitate is filtered off at the pump, washed with water and dried under high vacuum. 690 mg (94% of theory) of the target compound are thus obtained.

Provenance & Evidence