反应详情

770 mg (2.89 mmol) of methyl[4-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate from Example 232A are placed in 20 ml methanol, treated with 5.8 ml of 1 M aqueous lithium hydroxide solution and stirred for 18 hrs at room temperature. The methanol is then removed on the rotary evaporator and the residue is acidified with 1 N hydrochloric acid. The resulting precipitate is filtered off at the pump, washed with water and dried under high vacuum. 690 mg (94% of theory) of the target compound are thus obtained.

1. customThe methanol is then removed on the rotary evaporator
2. filtrationThe resulting precipitate is filtered off at the pump
3. washwashed with water
4. customdried under high vacuum
5. custom690 mg (94% of theory) of the target compound are thus obtained