反应详情

温度

0 °C

850 mg (4.007 mmol) of 2-amino-1-(4-chlor-2-thienyl)ethanone hydrochloride are placed in 26 ml dichloromethane, cooled to 0° C. and treated dropwise with a solution of 606 mg (4.007 mmol) of 2-fluorobenzyl isocyanate in 2 ml dichloromethane. It is stirred for 10 mins more at 0° C. and then a solution of 518 mg (4.007 mmol) of N,N-diisopropylethylamine in 4 ml dichloromethane is added dropwise. After two hours' stirring at room temperature the reaction mixture is evaporated and the crude product (1300 mg, 99% of theory) further reacted without purification.

1. stirringAfter two hours' stirring at room temperature the reaction mixture
2. customis evaporated
3. customthe crude product (1300 mg, 99% of theory) further reacted without purification