反应详情

1300 mg (ca. 4.0 mmol) of 1-[2-(5-chloro-2-thienyl)-2-oxoethyl]-3-(2-fluorobenzyl)-urea (Example 235A) are suspended in 15 ml of concentrated hydrochloric acid, diluted with 15 ml of methanol diluted and stirred at RT for 2 hrs. The suspension is filtered, the filtrate concentrated in vacuo and the residue purified by preparative HPLC [Method 10]. 220 mg (18% of theory) of the target compound are thus obtained.

1. additiondiluted
2. filtrationThe suspension is filtered
3. concentrationthe filtrate concentrated in vacuo
4. customthe residue purified by preparative HPLC [Method 10]
5. custom220 mg (18% of theory) of the target compound are thus obtained