HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dibromobutane → N-[4-(1-Adamantyloxy)-3,5-dimethylphenyl]pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dibromobutane | HCID 8056 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 20342224 | HCID 20342224 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[4-(1-Adamantyloxy)-3,5-dimethylphenyl]pyrrolidine | HCID 12510314 | — |
Reaction Steps
The amine obtained by washing a CH2Cl2 solution of 2.1 g. (6.82 mmole) of 4-(1-adamantyloxy)-3,5-dimethylaniline hydrochloride with three 25 ml. portions of 10% aq. NaOH followed by a water wash, drying (anhydrous MgSO4) and concentration, was combined with 1.47 g. (6.82 mmole) of 1,4-dibromobutane and 2.07 g. (15.0 mmole) of K2CO3 in 20 ml. of absolute ethanol and refluxed for approximately 18 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04130561 |
| Source dataset | uspto-grants-1978_12 |
| ORD ID | ord-84f17fd872024601a2eeeb16e6fa15d6 |
| Source note | uspto-grants-1978_12 |